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Sunday, April 26, 2020 | History

2 edition of Acute toxicity of selected organic compounds to fathead minnows found in the catalog.

Acute toxicity of selected organic compounds to fathead minnows

Vincent R Mattson

Acute toxicity of selected organic compounds to fathead minnows

  • 44 Want to read
  • 16 Currently reading

Published by Environmental Protection Agency, Office of Research and Development, Environmental Research Laboratory, for sale by the National Technical Information Service in Duluth, Minn, Springfield, Va .
Written in English

    Subjects:
  • Biological assay,
  • Bluntnose minnow,
  • Poisons -- Physiological effect,
  • Fishes -- Toxicology -- Effect of water pollution on,
  • Fishes -- Effect of water pollution on

  • Edition Notes

    Bibliography: p. 11-12

    Statementby Vincent R. Mattson, John W. Arthur, Charles T. Walbridge
    SeriesResearch reporting series
    ContributionsArthur, John W., jt. auth, Walbridge, Charles T., jt. auth, United States. Environmental Protection Agency. Office ofResearch and Development
    The Physical Object
    Paginationvi, 13 p. ;
    Number of Pages13
    ID Numbers
    Open LibraryOL13601218M

    tThe mode of toxic action (MOA) has been recognized as a key determinant of chemical toxicity andas an alternative to chemical class-based predictive toxicity modeling. However, the development ofquantitative structure activity relationship (QSAR) and other models has been limited by the avail-ability of comprehensive high quality MOA and toxicity databases.


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Acute toxicity of selected organic compounds to fathead minnows by Vincent R Mattson Download PDF EPUB FB2

The selected compounds represented the five following chemical classes: acids, alcohols, hydrocarbons, ketones and aldehydes, and phenols. Juvenile fathead minnows (Pimephales promelas) were the test animal, and test duration was limited to 96 hr. Lake Superior water served as the diluent source for all test compounds.

Acute toxicity of selected organic compounds to fathead minnows Paperback – January 1, by Vincent R. Mattson (Author)Author: Vincent R. Mattson. : Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales Promelas) (): Brooke, L.

T.: Books. The acute toxicity of selected substituted phenols, benzenes and benzoic acid esters to fathead minnows Pimephales promelas Author links open overlay panel Gary W.

Holcombe Gary L. Phipps Michael L. Knuth ∗ Taryl Felhaber †Cited by: A group contribution method has been developed to correlate the acute toxicity (h LC 50) to the fathead minnow (Pimephales promelas) for organic chemicals.

Multilinear regression and computational neural networks (CNNs) were used for model building. The models were able to achieve a fairly good correlation of the data (r 2 > ).Cited by: Prediction of the Acute Toxicity (h LC50) of Organic Compounds to the Fathead Minnow (Pimephales promelas) Using a Group Contribution Method | Chemical Research in Toxicology A group contribution method has been developed to correlate the acute toxicity (h LC50) to the fathead minnow (Pimephales promelas) for organic by: Fathead Minnow Acute Toxicity database was generated by the U.S.

EPA Mid-Continental Ecology Division (MED) for the purpose of developing an expert system to predict acute toxicity from chemical structure based on mode of actionan important and unusual characteristic of this toxicity database is that the tested.

Mattson, V.R., Arthur, J.W. and C.T. Walbridge. Acute Toxicity of Selected Organic Compounds to Fathead Minnows. EPA/ Test Substance (CAS # and name): (Hexanoic acid / Caproic acid) *Chemical composition of the substance (including purity, by-products) X Persistence/stability of test substance in aquatic solution X.

Fathead Minnow. MED-Duluth tested a series of industrial organic compounds using the fathead minnow for the purpose of developing an expert system to predict the acute mode of toxic action from chemical structure.

The results were also used to develop quantitative structure-activity relationships (QSARs) based on the acute mode of action. Mattson, Vincent R. Acute toxicity of selected organic compounds to fathead minnows. Duluth, Minn.: Environmental Protection Agency, Office of Research and Development, Environmental Research Laboratory ; Springfield, Va.

Vincent R Mattson; John W Arthur; Charles T Walbridge; United States. Environmental Protection Agency. Acute toxicity of selected organic compounds to fathead minnows / By Vincent R Mattson and United States.

Environmental Protection Agency. Office of Research and Development. Abstract. Bibliography: p. Mode of access: Internet. The acute toxicity to Fathead Minnow increases with the solubility of the compound in octanol (logP), this being a measure of the organic compound penetration in the animal tissue.

Acute toxicity of selected organic compounds to fathead minnows book acute toxicity to Fathead Minnow also increases with increasing values of descriptor Count of H. We conducted laboratory toxicity tests in support of the development of a biotic ligand model (BLM) to predict acute toxicity of zinc (Zn) to fathead minnows (Pimephales promelas).

To test the effect of dissolved organic matter (DOM) on Zn toxicity, we exposed larval fathead minnows to Zn in water containing elevated concentrations of dissolved organic carbon (DOC) in h static-renewal Cited by: The fathead minnows and Daphnia were quite similar in their sensitivities (acute and chronic) to each chemical class, while the Acute toxicity of selected organic compounds to fathead minnows book trout were considerably more sensitive to all class- es during acute tests, except for the chlorinated diene exposures, where they were more resistant.

Open Library is an open, editable library catalog, building towards a web page for every book ever published. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas) by,Distributed by The Center edition, in English.

Acute fathead minnow toxicity is an important basis of hazard and risk assessment for compounds in the aquatic environment. In this paper, a large dataset consisting of organic compounds with. hatched fathead minnow larvae less than 24 h old are used to monitor the chronic toxicity of the reference toxicant to the test fish produced by the culture unit (see Section 4, Quality Assurance).

Request PDF | QSAR model for predicting the toxicity of organic compounds to fathead minnow | In this work, a new norm descriptor is proposed based on atomic properties. A quantitative structure. mussel and fathead minnow (to d flow-through exposure with survival, weight, and biomass endpoints).

The results of the acute tests indicate that (1) the cladoceran and the mussel were more sensitive to sulfate than the fathead minnow and midge, and (2) the larval fathead minnows were more sensitive than theFile Size: KB. ECOSARs are linear mathematical relationships that correlate the log of the octanol/water partition coefficient and the log of the measured toxicity values (mmol/L).

The ECOSAR models are based on toxicity data for fathead minnow (Pimephales promelas) at 96 hour static conditions. However, these models predict toxicity for only the fathead minnow. The toxicities of several chlorinated benzene compounds to fathead minnows (Pimephales promelas) were determined.

Chronic toxicities were estimated from 32–33 day embryo through early juvenile development exposures. The ranges between the highest no observable effect concentration (NOEC) and lowest observed effect concentration (LOEC) were 1,–2, Cited by: The 96‐h LC50 for larval fathead minnows (P.

promelas) was 1, mg/L NO 3 ‐N. The NOEC and LOEC for 7‐d larval and 11‐d embryo‐larval growth tests were and mg/L NO 3 ‐N, respectively. Additional exposure of breeding P. promelas and their fertilized eggs to nitrate did not increase susceptibility further.

The LC50 values Cited by: In this paper, a large dataset consisting of organic compounds with acute toxicity towards fathead minnow was studied with a QSAR approach. All molecular structures of compounds were optimized by the hybrid density functional theory method.

Dragon molecular descriptors and log K ow were selected to describe molecular information. Genetic Cited by: 8. The traditional approach to QSARs for acute toxicity of organic compounds to the fathead minnow is the modeling of the activity of homologous or congeneric series of chemicals such as nitroaromatics, alkylamines, halogenated hydrocarbons and phenols, and chlorobenzenes and chloroalinines.

This congeneric series approach is by:   Acute fathead minnow toxicity is an important basis of hazard and risk assessment for compounds in the aquatic environment. In this paper, a large dataset consisting of organic compounds with acute toxicity towards fathead minnow was studied with a QSAR approach.

All molecular structures of compounds were optimized by the hybrid density functional theory by: 8. Fathead minnows (Pimephales promelas) were exposed to acutely toxic concentrations of organic chemicals under flow‐through conditions at 25°C for 96 s in behavior and morphology were systematically recorded to develop a plan for classifying these chemicals.

On this basis, three behavioral toxicity syndromes were evident. traditional approach to QSARs for acute toxicity of organic compounds to the fathead minnow is the modeling of the activity of homologous or congeneric series of chemicals such as nitroaromatics [1], alkylamines [2], halogenated hydrocarbons and phenols [3], and chlorobenzenes and chloroalinines [4].

This congeneric series approach is conservative. Chemicals to Fathead Minnows (Pimephales promelas), Volume 1. Center for Lake Superior Center for Lake Superior Environmental Studies, Univ.

of Wisconsin, Superior, WI: p. Fathead minnow acute toxicity database. Ninety-six-hour flow-through exposures using to d-old juvenile fathead minnows were conducted on chemicals [15–19]. Com-pounds were selected for testing from the Toxic Substances Control Act inventory of chemicals to represent a cross-section of industrial organic chemicals [20].

For quality. Acute toxicity information was determined for acenaphthene, arsenic trioxide, cadmium chloride, mercury (II) chloride, silver nitrate, chlordane, endosulfan, and heptachlor.

Acute tests were conducted using. The objective of this research was to develop procedures that relate modes of acute toxic action in the fathead minnow (Pimephales promelas) to chemical structures and properties.

An empirically derived database for diverse chemical structures of acute toxicity and corresponding modes of toxic action was developed through joint toxic action Cited by: Whole Effluent Toxicity (WET) testing uses fathead minnows and Ceriodaphnia dubia to measure if a discharge is or may be toxic.

Fathead Minnow Pimephales Promelas. Ceriodaphnia dubia. The test can be either acute or chronic. Acute tests are short-term tests, usually 96 hours or less. The acute test determines if the effluent would be lethal to. Several quantum-mechanics-based descriptors were derived for a diverse set of48 organic compounds using AM1, PM3, HF/ G, and DFT-B3LYP/ G (d) level ofthe theory.

LC50 values of acute toxicity of the compounds were correlated to the fatheadminnow and predicted using calculated descriptors by employing ComprehensiveDescriptors for Structural and Statistical Analysis Cited by: Revision: 09/12/ Page: 5 Glass Clean SAFETY DATA SHEET Supersedes Revision: 05/07/ J.W.

Arthur, and C.T. Walbridge, LC50, Fathead Minnow File Size: KB. Acute toxicity, uptake and histopathology of aqueous methyl mercury to fathead minnow embryos. Devlin EW(1). Author information: (1)Biology Department, Hampden-Sydney College, Hampden-Sydney, VAUSA. [email protected] Early life stages of fishes have been shown to be especially susceptible to the toxic effects of heavy metal by: The interactive effects of chloride, hardness, alkalinity, total organic carbon, and pH on the acute toxicity of silver (AgNO{sub 3}) were measured using juvenile fathead minnows (Pimephales promelas) and Daphnia magna.

The hr LC50 for fathead minnows at the lowest tested levels ofmore». Acute toxicity, category 4, oral H Serious eye damage, category 1 H Age on the Response of Fathead Minnows in Static Acute Toxicity Tests. 31(2) 88 mg/l (96 h) - Mattson, V.R., J.W.

Arthur, and C.T. Walbridge Acute Toxicity of Selected Organic Compounds to Fathead Minnows. EPA/ The effects of independently altering chloride, calcium, and dissolved organic carbon (DOC) on the toxicity of silver (presented as AgNO 3) were compared between rainbow trout (Oncorhynchus mykiss) and fathead minnows (Pimephales promelas).The 96‐h median lethal concentration (LC50) toxicity tests for both species were performed under the same conditions, within the same containers.

HOUR ACUTE TOXICITY TESTING USING PIMEPHALES PROMELAS SCOPE AND APPLICATION The p roce dure f or cond uct ing a 96 -ho ur acute st at ic- renewal toxi ci ty test us ing Pi mephal es pr om el as (Fat hea d Minnows) is described below. This test is applicable to surface water, effluents, leachates, and liquid phasesFile Size: KB.

The contribution of benzothiazoles and other organic sulphur compounds to the tire water toxicity could be investigated by adding nonlethal amounts of a mercury salt to the tire water to bind the sulphur compounds and thus reduce their bioavailability and toxicity.

Revision: 01/31/ Page: 2 Liquid Spray Fragrance,CFS2MX, CFS2ST, CFS2CH, CFS2CT, CFS2JS, CFS2NC, CFS2VN MATERIAL SAFETY DATA SHEET Supersedes Revision: 07/16/ 6.One compound displayed much higher acute toxicity to bluegill and trout than to fathead minnows (more than an order of magnitude), but unexpectedly, displayed very high toxicity to sheepshead minnows.

Another OP compound displayed moderate toxicity to two species of freshwater fi sh (LC50 values between 5 and 10 mg/L), but displayed only.Endpoint. The acute aquatic toxicity model predicts the concentration of chemicals that kill 50% (LC 50) of the test fish Pimephales promelas (Fathead minnow) within a designated The training set consists of LC 50 values for chemicals [].

Test duration - 96 hours.